WILF 47,716 Posted December 2, 2020 Report Share Posted December 2, 2020 58 minutes ago, Accip74 said: That’s a legitimate concern in my eyes, a far cry from being an anti-vaxxer. Even my mum who takes the flu jab every year has reservations about taking it this soon & she’s spent the best part of the year holed up in her house. I don’t know the whys and wherefore’s or how true it is but they are answering the question of how fast a vaccine has been arrived at by saying that the funding to get there has been unprecedented. Normally it takes years to find funding, run out of that, apply for another etc etc etc but not in this case. As I say, I don’t know how valid that is but it sounds reasonable ? Link to post Share on other sites
TOMO 26,821 Posted December 2, 2020 Report Share Posted December 2, 2020 1 minute ago, WILF said: I don’t know the whys and wherefore’s or how true it is but they are answering the question of how fast a vaccine has been arrived at by saying that the funding to get there has been unprecedented. Normally it takes years to find funding, run out of that, apply for another etc etc etc but not in this case. As I say, I don’t know how valid that is but it sounds reasonable ? im sure all of that is true wilf....and like arry said ...scientists working round the clock....however its just the testing bit on real life humans and long term effects if any .. 2 Link to post Share on other sites
Accip74 7,112 Posted December 2, 2020 Report Share Posted December 2, 2020 (edited) 15 minutes ago, WILF said: I don’t know the whys and wherefore’s or how true it is but they are answering the question of how fast a vaccine has been arrived at by saying that the funding to get there has been unprecedented. Normally it takes years to find funding, run out of that, apply for another etc etc etc but not in this case. As I say, I don’t know how valid that is but it sounds reasonable ? Yeah I’m sure they’ve ticked all the boxes mate apart from the long term one obviously. I’m just highlighting the fact you don’t need to be an anti-vaxxer to have concerns. I haven’t spoke to a single person yet that haven’t got reservations, none of which were anti-vaxxers. What I find more odd is people already rationalising the idea of it being made mandatory or at least mandatory by proxy? Edited December 2, 2020 by Accip74 Link to post Share on other sites
Greb147 6,809 Posted December 2, 2020 Report Share Posted December 2, 2020 It's not as though they have only just started working on a vaccine this last year. The strain of virus is very similar to other SARS strains which have been known for at least 15 years, although no vaccine has been released you would think that gives them a head start. 3 Link to post Share on other sites
Chaff 3,622 Posted December 2, 2020 Report Share Posted December 2, 2020 As far as I know we don't have a time machine, so with all the money in the world. No one knows what the long term effects of this vaccine are. Link to post Share on other sites
j j m 6,561 Posted December 2, 2020 Report Share Posted December 2, 2020 id have it Link to post Share on other sites
Born Hunter 17,816 Posted December 2, 2020 Report Share Posted December 2, 2020 1 hour ago, Accip74 said: That’s a legitimate concern in my eyes, a far cry from being an anti-vaxxer. Even my mum who takes the flu jab every year has reservations about taking it this soon & she’s spent the best part of the year holed up in her house. I feel like the dominant area of elevated risk (compared with a 'normal' vaccine) is in finding yourself in a group which for whatever reason don't respond well to vaccination (efficacy). As opposed to nasty side effects. I believe side effects are usually found out in Phase II. Reason I say this is that Phase III trials have vaccinated over ten thousand people for each vaccine candidate. If that were a medicine then it's a sufficient number of people to satisfy regulators in 'normal' times and there really wouldn't be anything 'rushed' about this. But because we're dealing with a vaccine there's another important number to look at, how many people who were vaccinated fought off the virus compared with the same in the placebo group. And this number is much smaller and not yet satisfactory to complete Phase III and is important because it tells us about efficacy. This is the rushed part because at the present time we're dealing with numbers like 100 infections in the placebo group vs five in the vaccine group (out of a total group size of like 30'000). That's good of course, you want low infection in the vaccinated group, lol, but you want high infection in the placebo group to get the stats up to find demographics that the vaccine might not be working on. Part of the reason this has moved faster than 'normal' vaccine development is the relative high infection rates in the world right now speeding things up, partly the massive demand and so money available, partly eliminating dead time in the process, and partly the fact that the governments of the world are willing to roll vaccines out before completion of phase III and so deep knowledge of it's efficacy and to a lesser extend imo safety. I've got to be honest, I find it f***ing remarkable the shit off the street folks will take for a good time but these vaccines leave them uncomfortable. 3 2 Link to post Share on other sites
Accip74 7,112 Posted December 2, 2020 Report Share Posted December 2, 2020 2 minutes ago, Born Hunter said: I feel like the dominant area of elevated risk (compared with a 'normal' vaccine) is in finding yourself in a group which for whatever reason don't respond well to vaccination (efficacy). As opposed to nasty side effects. I believe side effects are usually found out in Phase II. Reason I say this is that Phase III trials have vaccinated over ten thousand people for each vaccine candidate. If that were a medicine then it's a sufficient number of people to satisfy regulators in 'normal' times and there really wouldn't be anything 'rushed' about this. But because we're dealing with a vaccine there's another important number to look at, how many people who were vaccinated fought off the virus compared with the same in the placebo group. And this number is much smaller and not yet satisfactory to complete Phase III and is important because it tells us about efficacy. This is the rushed part because at the present time we're dealing with numbers like 100 infections in the placebo group vs five in the vaccine group (out of a total group size of like 30'000). That's good of course, you want low infection in the vaccinated group, lol, but you want high infection in the placebo group to get the stats up to find demographics that the vaccine might not be working on. Part of the reason this has moved faster than 'normal' vaccine development is the relative high infection rates in the world right now speeding things up, partly the massive demand and so money available, partly eliminating dead time in the process, and partly the fact that the governments of the world are willing to roll vaccines out before completion of phase III and so deep knowledge of it's efficacy and to a lesser extend imo safety. I've got to be honest, I find it f***ing remarkable the shit off the street folks will take for a good time but these vaccines leave them uncomfortable. I think it’s probably more the fact that people feel under pressure to comply & just get on & take it. That’s unprecedented in this time scale. I sincerely hope it is effective. Vaccines are not something I’ve ever really given much thought to, so I’m definitely not against them, but I’d still like to see how it pans out for a few years. I have no fear of the virus myself, so it would just be for others sake in my case. 2 Link to post Share on other sites
WILF 47,716 Posted December 2, 2020 Report Share Posted December 2, 2020 17 minutes ago, Accip74 said: What I find more odd is people already rationalising the idea of it being made mandatory or at least mandatory by proxy? I’m the same as you and Tomo mate, just a standard Joe Soap who is waiting to see what happens and with concerns about effects etc etc......I reckon that’s only natural to feel that way. As to your comment above, I’d never support any “mandatory”......that’s bollocks. Anyone who supports that type of thinking needs to go away and think harder. Like all legislation, todays something you don’t mind is tomorrow’s something you don’t want 1 1 Link to post Share on other sites
Chaff 3,622 Posted December 2, 2020 Report Share Posted December 2, 2020 This is what the experts are saying Mike Yeadon and Dr Woldarg These two fellas know a thing or two about vaccines. The vaccinations are expected to produce antibodies against spike proteins of SARS-CoV-2. However, spike proteins also contain syncytin-homologous proteins, which are essential for the formation of the placenta in mammals such as humans. It must be absolutely ruled out that a vaccine against SARS-CoV-2 could trigger an immune reaction against syncytin-1, as otherwise infertility of indefinite duration could result in vaccinated women. Link to post Share on other sites
pesky1972 5,352 Posted December 2, 2020 Report Share Posted December 2, 2020 My understanding is that the speed at which these vaccines have been developed is due to an unprecedented effort and the removal of a lot of the ‘red tape’ cat & mouse money stuff between big pharmaceutical companies and governments. It’s maybe not that these have been done ‘quickly’, but what we’re comparing them to has been done slower than it was possible to. It is right to question to pros and cons (risks) of any medicine you put in your body. My 14 yr old tested positive last week and I’m in isolation. No symptoms myself, but may well be an asymptomatic carrier, so the vaccine is unlikely to protect me. Kids haven’t hugged their gran in over 6 months though, and that’s killing all of us, so I’ll put my trust in the people who know what they’re doing and take the jab to protect her, and get life back to some sort of normal. Link to post Share on other sites
Greb147 6,809 Posted December 2, 2020 Report Share Posted December 2, 2020 5 minutes ago, pesky1972 said: My understanding is that the speed at which these vaccines have been developed is due to an unprecedented effort and the removal of a lot of the ‘red tape’ cat & mouse money stuff between big pharmaceutical companies and governments. It’s maybe not that these have been done ‘quickly’, but what we’re comparing them to has been done slower than it was possible to. It is right to question to pros and cons (risks) of any medicine you put in your body. My 14 yr old tested positive last week and I’m in isolation. No symptoms myself, but may well be an asymptomatic carrier, so the vaccine is unlikely to protect me. Kids haven’t hugged their gran in over 6 months though, and that’s killing all of us, so I’ll put my trust in the people who know what they’re doing and take the jab to protect her, and get life back to some sort of normal. Like I said, there has been over a decades worth of research gone in to developing vaccinations for other strains of related SARS viruses so i imagine they have plenty of research already. Link to post Share on other sites
chartpolski 24,644 Posted December 2, 2020 Report Share Posted December 2, 2020 I'm in the 5th tier of priority , over 65's, for the vaccine, so hopefully by the time they get to me, any side affects will have been identified. So, I'll stay on the fence for now, evaluate what happens, then decide if I'll have the vaccine. Im just being a bit cautious, I don't for one minute think it's a conspiracy to control us or implant us with a microchip ! ! Cheers. Link to post Share on other sites
Greyman 29,031 Posted December 2, 2020 Report Share Posted December 2, 2020 Just now, chartpolski said: I'm in the 5th tier of priority , over 65's, for the vaccine, so hopefully by the time they get to me, any side affects will have been identified. So, I'll stay on the fence for now, evaluate what happens, then decide if I'll have the vaccine. Im just being a bit cautious, I don't for one minute think it's a conspiracy to control us or implant us with a microchip ! ! Cheers. Just had a text from my doctor for the flu jabs I have never taken in my life and to tell me my vaccine is ready from the 14th of this month, can’t see me booking that anytime soon Link to post Share on other sites
tatsblisters 10,317 Posted December 2, 2020 Report Share Posted December 2, 2020 Wonder if care workers will be first in line . Link to post Share on other sites
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