FIBROSARCOMAS AT VACCINE INJECTION SITES IN DOGS

[Kris L. Christine 2]

Below is the Journal of Veterinary Medicine abstract of an important documenting fibrosarcomas at presumed rabies vaccination sites. Some veterinarians deny that dogs develop cancerous tumors at vaccination sites --this study suggests otherwise! The researchers used the presumed injection sites of rabies vaccines in the study.

 

The following quote is from the full study text: "In both dogs and cats, the development of necrotizing panniculitis at sites of rabies vaccine administration was first observed by Hendrick & Dunagan (1992)."

 

Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas

 

Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291(6)

 

Vascellari M.[1]; Melchiotti E.[1]; Bozza M.A.[1]; Mutinelli F.[2]

 

[1] Address of authors: Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'Università 10, 35020 Legnaro (PD), Italy; [2] Corresponding author:, Tel: +39 049 8084261, Fax: +39 049 8084258, Email: fmutinelli@izsvenezie.it

 

Abstract:

Summary

 

Fifteen fibrosarcomas, surgically excised from presumed sites of injection in dogs, and 10 canine fibrosarcomas excised from sites not used for injection were histologically and immunohistochemically compared with 20 feline post-vaccinal fibrosarcomas. Canine fibrosarcomas from presumed injection sites were of grade I (3), of grade II (4) and grade III (. Two fibrosarcomas from non-injection sites were of grade I, four of grade II and four of grade III. Feline samples were classified as grade I (2), grade II (4) and grade III (14). All fibrosarcomas from presumed injection sites of both species showed lymphocytic inflammatory infiltration located at the tumour periphery, while two canine fibrosarcomas from non-injection sites showed perivascular inflammatory infiltration within the neoplasm. All samples were immunohistochemically examined for vimentin, smooth muscle actin, muscle specific actin and desmin expression. All tumours were positive for vimentin. Ten canine fibrosarcomas from presumed injection sites and all feline samples contained cells consistent with a myofibroblastic immunophenotype. Aluminium deposits were detected in eight canine fibrosarcomas from presumed injection sites and 11 feline post-vaccinal fibrosarcomas by the aurintricarboxylic acid method. The present study identifies distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection sarcomas not only in cats, but also in dogs.

 

Document Type: Research article ISSN: 0931-184X

 

DOI (article): 10.1046/j.1439-0442.2003.00544.x

SICI (online): 0931-184X(20030801)50:6L.286;1-

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In an August 1, 2008 article in DVM360 entitled Vaccination: An Overview,Dr. Melissa Kennedy states that of the two types of vaccinal adverse reactions: The second is a delayed response, requiring days of longer to develop. The vaccine, seen as foreign, elicits a significant inflammatory response and is especially true for adjuvanted vaccines. This response can manifest as a granuloma, or more seriously, a fibrosarcoma . Further, she reports that The likelihood of adverse reactions in dogs has been found to correlate with the size of the dog and the number of inoculations given, with higher risk associated with small size and multiple inoculations. http://veterinarycalendar.dvm360.com/avhc/article/articleDetail.jsp?id=568351'>http://veterinarycalendar.dvm360.com/avhc/article/articleDetail.jsp?id=568351

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Below are links to excellent information on veterinary vaccines from authoritative sources:

 

Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz http://www.cedarbayvet.com/duration_of_immunity.htm

 

What Everyone Needs to Know about Canine Vaccines, Dr. Ronald Schultz

http://www.puliclub.org/CHF/AKC2007Conf/What%20Everyone%20Needs%20to%20Know%20About%20Canine%20Vaccines.htm

 

Age and Long-term Protective Immunity in Dogs and Cats, Dr. Ronald Schultz et als., Journal of Comparative Pathology January 2010 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHW-4XVBB71-1&_user=10&_coverDate=01%2F31%2F2010&_rdoc=17&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236861%232010%23998579999.8998%231578454%23FLA%23display%23Volume)&_cdi=6861&_sort=d&_docanchor=&_ct=24&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fb57fe5e84a086c6b1fa65abea55dbd8

 

Genetically Engineered and Modified Live Virus Vaccines;Public Health and Animal Welfare Concerns by Michael W. Fox BVetMed,PhD,DSc.MRCVS

http://www.twobitdog.com/drfox/specialreport_Article.aspx?ID=273f53f4-bcdc-474f-a189-cca1d1a81c38

 

Vaccination: An Overview Dr. Melissa Kennedy, DVM360 http://veterinarycalendar.dvm360.com/avhc/article/articleDetail.jsp?id=568351

 

World Small Animal Veterinay Association's 2010 Guidelines for the Vaccination of Dogs and Cats http://www.wsava.org/VGG1.htm (scroll down to Vaccine Guidelines 2010 http://www.wsava.org/PDF/Misc/VaccinationGuidelines2010.pdf

 

World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm Scroll down to Vaccine Guidelines 2007 (PDF)

 

The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at http://www.leerburg.com/special_report.htm .

 

The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at

http://www.aahanet.org/PublicDocuments/VaccineGuidelines06Revised.pdf

 

Veterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at http://www.newvaccinationprotocols.com/

 

October 1, 2002 DVM Newsletter article entitled, AVMA, AAHA to Release Vaccine Positions, http://www.dvmnewsmagazine.com/dvm/article/articleDetail.jsp?id=35171

 

July 1, 2003 DVM Newsletter article entitled, What Do We Tell Our Clients?, Developing thorough plan to educate staff on changing vaccine protocols essential for maintaining solid relationships with clients and ensuring quality care http://www.dvmnewsmagazine.com/dvm/article/articleDetail.jsp?id=61696

 

July 1, 2003, DVM Newsletter article, Developing Common Sense Strategies for Fiscal Responsibility: Using an interactive template to plan service protocol changes http://www.dvmnewsmagazine.com/dvm/article/articleDetail.jsp?id=61694

 

Animal Wellness Magazine Article Vol. 8 Issue 6, How Often Does he REALLY Need A Rabies Shot Animal Wellness Magazine - devoted to natural health in animals

 

The Rabies Challenge Animal Wise Radio Interview

Listen to Animal Wise (scroll down to The Rabies Challenge 12/9/07)

 

The Vaccine Challenge Animal Talk Naturally Online Radio Show » The Vaccine Challenge - Show #91

 

Rabies Prevention -- United States, 1991 Recommendations of the Immunization Practices Advisory Committee (ACIP), Center for Disease Control's Morbidity and Mortality Weekly March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/mmwr/preview/mmwrhtml/00041987.htm "A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. "