Implants

[The one 8,479]

Good luck mate keep us posted with the results

[johnmac666 2]

Day 3 update on implants from wednesday

 

Hob , noticed yellowish coat reducing & testicles shrinking, still showing some ineterst in the girls,change in pooh colouring, eating as normal

 

Jill, vulva staring to swell , anyone know how long before she will go back to normal ?

 

regards john

Edited February 13, 2010 by johnmac666

[Kay 3,709]

Going by what the says about this drug, I wouldn't use it on any ferret intended for future breeding. Also, to ensure that the ferret develops normally, I'd be very cautious about using it on a ferret until after it was fully mature and had gone through a rut/heat.

 

 

can you elaborate regarding future breeding ?? & what age do the manufacturers reccomend the implant ?

 

it seems to me my vet is singing the prasies of this implant for reasons of finacial rather than welfare ?? maybe wrong but mine are only 8 months old & according to your post too young to be implanted , yet the vet didnt mention minimum ages & i told him mine are only young & i dont want to breed from my ferrets, my hob is in a season & my jill came into season in december ( now out of season ) does that mean she is ok to be implanted or is she still too young any info would be appreciated

 

regards john

 

John as far as i can see the whole idea of implanting now is to allow the ferret to mature then go the surgery route... its the early neutering thats seemingly the biggest cause of Adrenal... but in reality none of us know if our ferrets are pre disposed to Adrenal anyway

 

I am hearing good results when its implanted into Adrenal ferrets but its seemingly only masking the clinical symptoms because i did find a reference to the clinical symptoms coming back once the implant had worm off... and the study as far as i know didnt re implant ferrets who had previously shown clinical symptoms to compare it with

 

Time will tell i suppose... keep us updated as to your finding John will you please as i am very interested in the progress of this drug

[Kay 3,709]

Day 3 update on implants from wednesday

 

Hob , noticed yellowish coat reducing & testicles shrinking, still showing some ineterst in the girls,change in pooh colouring, eating as normal

 

Jill, vulva staring to swell , anyone know how long before she will go back to normal ?

 

regards john

 

I am not sure how long before the jills vulva goes back to normal if its been implanted .. i might ask a lady who had a jill done a few weeks back & see if hers swolen after implant

[johnmac666 2]

Day 3 update on implants from wednesday

 

Hob , noticed yellowish coat reducing & testicles shrinking, still showing some ineterst in the girls,change in pooh colouring, eating as normal

 

Jill, vulva staring to swell , anyone know how long before she will go back to normal ?

 

regards john

 

I am not sure how long before the jills vulva goes back to normal if its been implanted .. i might ask a lady who had a jill done a few weeks back & see if hers swolen after implant

 

 

cheers thanks for that kay, Adrian at Ashleigh vets Mcr wasnt able to speak to me today ,i am ringing him monday to ask how long before it will go down or if this is even normal i have tried getting onto (fff) but cant for some reason as i know a few people have had their ferrets implanted & posted about it, my diary will be like a dissertation, i may even bind it lol the vet did say that when used for treatment of adrenal it only masks the sypmtoms, but is showing good results,will keep you all updated

 

speak soon regards john

[lorelei0922 2]

i've heard that the jill swelling is normal and lasts a couple weeks..

[johnmac666 2]

i've heard that the jill swelling is normal and lasts a couple weeks..

 

 

thanks, i asked loads of questions at the vets but seeing as i am a male,i forgot will keep you all updated, implant hole has healed now scab fell off today, he is still making all the usual noises towards females & they are still teasing him, he can smell 3 of them poor lad must be doing his head in his yellow coat is still visible as you can see hopefully he should lose it within next couple of weeks

 

[Kay 3,709]

Day 3 update on implants from wednesday

 

Hob , noticed yellowish coat reducing & testicles shrinking, still showing some ineterst in the girls,change in pooh colouring, eating as normal

 

Jill, vulva staring to swell , anyone know how long before she will go back to normal ?

 

regards john

 

I am not sure how long before the jills vulva goes back to normal if its been implanted .. i might ask a lady who had a jill done a few weeks back & see if hers swolen after implant

 

 

cheers thanks for that kay, Adrian at Ashleigh vets Mcr wasnt able to speak to me today ,i am ringing him monday to ask how long before it will go down or if this is even normal i have tried getting onto (fff) but cant for some reason as i know a few people have had their ferrets implanted & posted about it, my diary will be like a dissertation, i may even bind it lol the vet did say that when used for treatment of adrenal it only masks the sypmtoms, but is showing good results,will keep you all updated

 

speak soon regards john

 

 

As lorrilea said it looks like a few weeks i did ask a friend but there ferrets were already done & its been implanted as a precaution as they have had a few adrenal ferrets ....but she did find this extract ........ i think as long as it is keeping adrenal ferrets comfortable thats the main thing .. there is a diary on another forum of the changes in one adrenal ferret & the coats almost grown back in a few weeks so as your vet aslo said it only masks the symptoms i reccon as long as the ferret is doing ok on it i dint see why they cant be re implanted again when the times right on the vets say so

 

Keep us updated its all interesting stuff

 

Deslorelin's a gonadotropin releasing hormone (GnRH) agonist (stimulator) so initially it stimulates production of the sex hormones so you are likely to see an increase in sexual 'activity' to start with.

After a while (2-4 weeks) deslorelin downregulates the GnRH receptors and blocks gonadotrophic hormone production so the production of the sex hormones is reduced.

[Funfuret 1]

There's some information on how it works and its time course in dogs on it's datasheet in the National Office for Animal Health (NOAH) Compendium.I've posted the relevant text below (see the text in italics).

 

Basically, seems that it can take 7 to 35 days for it to reach it peaks levels in an animal after being implanted, and about 4-6 weeks to exert its inhibitory effects on sexual 'attributes'. Also, it seems its not unexpected to see a spike in sex hormones soon after implantation, before its inhibitory effects set in. This of course is likely to cause transient signs of being in season in ferrets, such as going into oestrous for a short time in jills, and a temporary increase in smell amd perhaps increased amorous behaviour in the male.

 

Most of mine were neutered when I had them implanted, but I did have one intact hob kit implanted. It took about 3 weeks for his smell to fade and for his coat to get less oily. Now, 3 months later, he's still quite yellow but otherwise he's no different from my neutered males.

 

Hope this helps

 

"Pharmacological particulars

Pharmacodynamic properties

The GnRH agonist, deslorelin, acts by suppressing the function of the pituitary-gonadal axis when applied in a low, continuous dose. This suppression results in the failure of treated animals to synthesise and/or release follicle stimulating hormone (FSH) and luteinising hormone (LH), the hormones responsible for the maintenance of fertility.

The continuous low dose of deslorelin will reduce the functionality of the male reproductive organs, libido and spermatogenesis and lower the plasma testosterone levels, from 4-6 weeks after implantation. A short transient increase in plasma testosterone may be seen immediately after implantation. Measurement of plasma concentrations of testosterone has demonstrated the persistent pharmacological effect of the continuing presence of deslorelin in the circulation for at least six months following administration of the product.

Pharmacokinetic properties

It has been shown that plasma deslorelin levels peak 7 to 35 days following administration of an implant containing 5 mg radiolabelled deslorelin. The substance can be directly measured in the plasma up to approximately 2.5 months post implantation. The metabolism of deslorelin is rapid."

Edited February 14, 2010 by Funfuret

[johnmac666 2]

There's some information on how it works and its time course in dogs on it's datasheet in the National Office for Animal Health (NOAH) Compendium.I've posted the relevant text below (see the text in italics).

 

Basically, seems that it can take 7 to 35 days for it to reach it peaks levels in an animal after being implanted, and about 4-6 weeks to exert its inhibitory effects on sexual 'attributes'. Also, it seems its not unexpected to see a spike in sex hormones soon after implantation, before its inhibitory effects set in. This of course is likely to cause transient signs of being in season in ferrets, such as going into oestrous for a short time in jills, and a temporary increase in smell amd perhaps increased amorous behaviour in the male.

 

Most of mine were neutered when I had them implanted, but I did have one intact hob kit implanted. It took about 3 weeks for his smell to fade and for his coat to get less oily. Now, 3 months later, he's still quite yellow but otherwise he's no different from my neutered males.

 

Hope this helps

 

"Pharmacological particulars

Pharmacodynamic properties

The GnRH agonist, deslorelin, acts by suppressing the function of the pituitary-gonadal axis when applied in a low, continuous dose. This suppression results in the failure of treated animals to synthesise and/or release follicle stimulating hormone (FSH) and luteinising hormone (LH), the hormones responsible for the maintenance of fertility.

The continuous low dose of deslorelin will reduce the functionality of the male reproductive organs, libido and spermatogenesis and lower the plasma testosterone levels, from 4-6 weeks after implantation. A short transient increase in plasma testosterone may be seen immediately after implantation. Measurement of plasma concentrations of testosterone has demonstrated the persistent pharmacological effect of the continuing presence of deslorelin in the circulation for at least six months following administration of the product.

Pharmacokinetic properties

It has been shown that plasma deslorelin levels peak 7 to 35 days following administration of an implant containing 5 mg radiolabelled deslorelin. The substance can be directly measured in the plasma up to approximately 2.5 months post implantation. The metabolism of deslorelin is rapid."

 

 

much apppreciate you posting a reply, today he seems more interested in the girls, making more noise than usual,the jill her vulva is now 2/3 swollen, this is only day 4,will keep you all updated, regards john

Edited February 14, 2010 by johnmac666

[johnmac666 2]

just a quick update on my Hob & Jill, My jill is still in season

i have included a pic for anyone who doesnt know what a jill in season looks like.

The Hob is still showing signs of agreesion & being in season,placed him with the girls & they didnt stand a chance, so no real change in him, early days yet 1 week passed will update next week

 

 

 

regards john

[Kay 3,709]

just a quick update on my Hob & Jill, My jill is still in season

i have included a pic for anyone who doesnt know what a jill in season looks like.

The Hob is still showing signs of agreesion & being in season,placed him with the girls & they didnt stand a chance, so no real change in him, early days yet 1 week passed will update next week

 

 

 

regards john

 

John i have just thought of something i read it can take ages before the hobs infertile somewhere... i will find the info & post it

[Kay 3,709]

I knew i had read it somewhere its in this link

http://www.stlzoo.org/downloads/Deslorelin.pdf

[johnmac666 2]

thanks kay,interesting stuff,will keep you updated

 

regards john

[johnmac666 2]

Hi people another update on the implants i have had done, the Hob is loosing his yellow coat, agression signs fading ,i put him with the girls , he didnt grab their necks straight away he played for a while then decided he would try & hump them all,each time he tried, he seemd to have forgotten what he was doing then stopped trying to hump them & played again !!!

my Jill has gone back to normal her vulva is back relaxed, so from the date of implant it brought her in season for 10 days then the signs fade, i suppose this will differ from ferret to ferret but i suspect 14 days will be the normal time for heat to come on & then go, im still waiting to put my hob back with the girls , will keep you all informed,

did try to get out this weekend for 1 last bash before i call it a day, but the dam snow put a stop to this,

 

regards john