Why?.
22.250 is very noisy without a mod, recoil unless you have a very heavy set up usually prevents seeing bullet impact and that extra powder use reduces barrel life. Been there, got the tee shirt, sold the rifle.
223 will kill at 300 yards in ideal conditions, you wont be going much further than that normally. If you are going to reload then a 20 (204 Ruger) makes a bit more sense, shoots a bit flatter and hits a bit harder than 223.
A